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Innate B cells cleave to the marginal zone

Nature Immunology volume 18, pages 248–250 (2017)Cite this article

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The kinase Taok3 and protease ADAM10 mediate determination of the fate of marginal zone B cells.

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Figure 1: New model for MZB-cell-fate 'choice'.

Marina Corral Spence/Springer Nature

References

  1. Hammad, H. et al. Nat. Immunol. 18, 313–320 (2017).

    Article  CAS  PubMed  Google Scholar 

  2. Pillai, S. & Cariappa, A. Nat. Rev. Immunol. 9, 767–777 (2009).

    Article  CAS  PubMed  Google Scholar 

  3. Fasnacht, N. et al. J. Exp. Med. 211, 2265–2279 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  4. Cerutti, A., Cols, M. & Puga, I. Nat. Rev. Immunol. 13, 118–132 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Martin, F. & Kearney, J.F. Immunity 12, 39–49 (2000).

    Article  CAS  PubMed  Google Scholar 

  6. Carey, J.B., Moffatt-Blue, C.S., Watson, L.C., Gavin, A.L. & Feeney, A.J. J. Exp. Med. 205, 2043–2052 (2008).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  7. Gibb, D.R. et al. J. Exp. Med. 207, 623–635 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  8. Zikherman, J., Parameswaran, R. & Weiss, A. Nature 489, 160–164 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Xu, Y., Harder, K.W., Huntington, N.D., Hibbs, M.L. & Tarlinton, D.M. Immunity 22, 9–18 (2005).

    PubMed  Google Scholar 

  10. Arnon, T.I., Horton, R.M., Grigorova, I.L. & Cyster, J.G. Nature 493, 684–688 (2013).

    Article  CAS  PubMed  Google Scholar 

  11. Hers, I., Vincent, E.E. & Tavaré, J.M. Cell. Signal. 23, 1515–1527 (2011).

    Article  CAS  PubMed  Google Scholar 

  12. Anzelon, A.N., Wu, H. & Rickert, R.C. Nat. Immunol. 4, 287–294 (2003).

    Article  CAS  PubMed  Google Scholar 

Download references

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Authors and Affiliations

  1. Anthony L. DeFranco is in the Department of Microbiology & Immunology, University of California–San Francisco, San Francisco, California, USA.,

    Anthony L DeFranco

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  1. Anthony L DeFranco
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Correspondence to Anthony L DeFranco.

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The author declares no competing financial interests.

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DeFranco, A. Innate B cells cleave to the marginal zone. Nat Immunol 18, 248–250 (2017). https://doi.org/10.1038/ni.3685

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