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Finding the 'ubiquitous' threads in infection and autoimmune neuroinflammation

Nature Immunology volume 18, pages 7–8 (2017)Cite this article

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The deubiquitinase USP15 acts with the ubiquitin ligase TRIM25 to activate a type I interferon response and exacerbate microbial and autoimmune neuroinflammation.

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Figure 1: The USP15-mediated type I interferon response is a common pathway that regulates infection and autoimmune neuroinflammation.

Marina Corral Spence/ Springer Nature

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Authors and Affiliations

  1. Sophia Bardehle is with the Gladstone Institute of Neurological Disease, San Francisco, California, USA.,

    Sophia Bardehle

  2. Victoria Rafalski is with the Gladstone Institute of Neurological Disease, San Francisco, California, USA.,

    Victoria Rafalski

  3. and the Department of Neurology, Katerina Akassoglou is with the Gladstone Institute of Neurological Disease, San Francisco, California, USA, University of California, San Francisco, San Francisco, California, USA.,

    Katerina Akassoglou

Authors
  1. Sophia Bardehle
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  2. Victoria Rafalski
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  3. Katerina Akassoglou
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Corresponding author

Correspondence to Katerina Akassoglou.

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The authors declare no competing financial interests.

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Bardehle, S., Rafalski, V. & Akassoglou, K. Finding the 'ubiquitous' threads in infection and autoimmune neuroinflammation. Nat Immunol 18, 7–8 (2017). https://doi.org/10.1038/ni.3633

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