Follicular helper T cells (TFH cells) sequentially acquire the potential to secrete interleukin 21 (IL-21) and IL-4. The shift from secretion of IL-21 to that of IL-4 modifies the nature of the 'help' signals delivered by TFH cells to germinal center (GC) B cells.
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Bélanger, S., Crotty, S. Dances with cytokines, featuring TFH cells, IL-21, IL-4 and B cells. Nat Immunol 17, 1135–1136 (2016). https://doi.org/10.1038/ni.3561
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DOI: https://doi.org/10.1038/ni.3561
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