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Reining in uncontrolled inflammasome with PKA

Nature Immunology volume 17, pages 1137–1138 (2016)Cite this article

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New findings show that the NLRP3 inflammasome is inactivated by disassembly of the inflammasome mediated by the kinase PKA and that this regulation might be negated in NLRP3-gain-of-function diseases.

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Figure 1: PKA negatively regulates the NLRP3 inflammasome.

Debbie Maizels/ Nature Publishing Group

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Authors and Affiliations

  1. and the Department of Genetics, Karen V. Swanson is with the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.,

    Karen V Swanson

  2. the Department of Genetics, Jenny P.-Y. Ting is with the Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, the Center for Translational Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA, and the Institute for Inflammatory Diseases, University of North Carolina at Chapel Hill, North Carolina, USA.,

    Jenny P-Y Ting

Authors
  1. Karen V Swanson
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  2. Jenny P-Y Ting
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Correspondence to Jenny P-Y Ting.

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The authors declare no competing financial interests.

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Swanson, K., Ting, JY. Reining in uncontrolled inflammasome with PKA. Nat Immunol 17, 1137–1138 (2016). https://doi.org/10.1038/ni.3556

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