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Mass cytometry: blessed with the curse of dimensionality

Abstract

Immunologists are being compelled to develop new high-dimensional perspectives of cellular heterogeneity and to determine which applications best exploit the power of mass cytometry and associated multiplex approaches.

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Figure 1: The curse of dimensionality.
Figure 2: The emergence of high-resolution cellular phenotypes through nonlinear summation of parameters.

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Acknowledgements

We thank all members of the Newell laboratory, especially M. Fehlings and Y. Simoni, for comments and suggestions, and previous and ongoing collaborators for data that have influenced the opinions and general observations here. Supported by A-STAR/SIgN core funding and the ASTAR/SIgN immunomonitoring platform (E.W.N.).

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Correspondence to Evan W Newell.

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Newell, E., Cheng, Y. Mass cytometry: blessed with the curse of dimensionality. Nat Immunol 17, 890–895 (2016). https://doi.org/10.1038/ni.3485

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