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Innate lymphoid cells in defense, immunopathology and immunotherapy

Nature Immunology volume 17, pages 755–757 (2016)Cite this article

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Targeting of innate lymphoid cells, the innate counterparts of T cells, might allow early direction of the immune system into the appropriate response during preventive and therapeutic strategies aimed at pathogens and inflammatory pathologies.

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Figure 1: ILC-based immunotherapy.

References

  1. Eberl, G., Colonna, M., Di Santo, J.P. & McKenzie, A.N. Science 348, aaa6566 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  2. Brennan, P.J., Brigl, M. & Brenner, M.B. Nat. Rev. Immunol. 13, 101–117 (2013).

    Article  CAS  PubMed  Google Scholar 

  3. Hepworth, M.R. et al. Nature 498, 113–117 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  4. Oliphant, C.J. et al. Immunity 41, 283–295 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Satoh-Takayama, N. et al. Immunity 29, 958–970 (2008).

    Article  CAS  PubMed  Google Scholar 

  6. Zheng, Y. et al. Nat. Med. 14, 282–289 (2008).

    Article  CAS  PubMed  Google Scholar 

  7. Hernández, P.P. et al. Nat. Immunol. 16, 698–707 (2015).

    Article  PubMed  PubMed Central  Google Scholar 

  8. Van Maele, L. et al. J. Infect. Dis. 210, 493–503 (2014).

    Article  CAS  PubMed  Google Scholar 

  9. Klose, C.S. et al. Nature 494, 261–265 (2013).

    Article  CAS  PubMed  Google Scholar 

  10. Klose, C.S. et al. Cell 157, 340–356 (2014).

    Article  CAS  PubMed  Google Scholar 

  11. Abt, M.C. et al. Cell Host Microbe 18, 27–37 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Moro, K. et al. Nature 463, 540–544 (2010).

    Article  CAS  PubMed  Google Scholar 

  13. Neill, D.R. et al. Nature 464, 1367–1370 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  14. Monticelli, L.A. et al. Nat. Immunol. 12, 1045–1054 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Sonnenberg, G.F. et al. Science 336, 1321–1325 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  16. Buonocore, S. et al. Nature 464, 1371–1375 (2010).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Geremia, A. et al. J. Exp. Med. 208, 1127–1133 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Bernink, J.H. et al. Nat. Immunol. 14, 221–229 (2013).

    Article  CAS  PubMed  Google Scholar 

  19. Fuchs, A. et al. Immunity 38, 769–781 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Lee, M. et al. Cell 160, 74–87 (2014).

    Article  PubMed  PubMed Central  Google Scholar 

  21. Qiu, Y. et al. Cell 157, 1292–1308 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Burcelin, R., Garidou, L. & Pomié, C . Semin. Immunol. 24, 67–74 (2012).

    Article  CAS  PubMed  Google Scholar 

  23. Wensveen, F.M. et al. Nat. Immunol. 16, 376–385 (2015).

    Article  CAS  PubMed  Google Scholar 

  24. Kim, H.Y. et al. Nat. Med. 20, 54–61 (2014).

    Article  CAS  PubMed  Google Scholar 

  25. Halim, T.Y. et al. Immunity 40, 425–435 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  26. Salimi, M. et al. J. Exp. Med. 210, 2939–2950 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Kim, B.S. et al. Sci. Transl. Med. 5, 170ra116 (2013).

    Article  Google Scholar 

  28. Li, D. et al. J. Allergy Clin. Immunol. 134, 1422–1432 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. McHedlidze, T. et al. Immunity 39, 357–371 (2013).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  30. Kruglov, A.A. et al. Science 342, 1243–1246 (2013).

    Article  CAS  PubMed  Google Scholar 

  31. Magri, G. et al. Nat. Immunol. 15, 354–364 (2014).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  32. Lochner, M. et al. J. Exp. Med. 208, 125–134 (2011).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  33. Aparicio-Domingo, P. et al. J. Exp. Med. 212, 1783–1791 (2015).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  34. Hanash, A.M. et al. Immunity 37, 339–350 (2012).

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Acknowledgements

Supported by the Agence Nationale de la Recherche (S.C. and J.M.) and the European Molecular Biology Organization (T.A.).

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Authors and Affiliations

  1. Sascha Cording, Jasna Medvedovic, Tegest Aychek and Gérard Eberl are with the Microenvironment & Immunity Unit, Institut Pasteur, Paris, France, and INSERM U1224, Paris, France.,

    Sascha Cording, Jasna Medvedovic, Tegest Aychek & Gérard Eberl

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  1. Sascha Cording
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  2. Jasna Medvedovic
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  3. Tegest Aychek
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  4. Gérard Eberl
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Correspondence to Gérard Eberl.

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Cording, S., Medvedovic, J., Aychek, T. et al. Innate lymphoid cells in defense, immunopathology and immunotherapy. Nat Immunol 17, 755–757 (2016). https://doi.org/10.1038/ni.3448

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