The NLRP3 inflammasome has broad biomedical relevance, but its activation mechanisms are incompletely understood. NEK7, a kinase that regulates microtubules during mitosis, is identified as a critical and selective upstream regulator of NLRP3 inflammasome activation.
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Van Hauwermeiren, F., Lamkanfi, M. The NEK-sus of the NLRP3 inflammasome. Nat Immunol 17, 223–224 (2016). https://doi.org/10.1038/ni.3391
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DOI: https://doi.org/10.1038/ni.3391
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