The TH17 subset of helper T cells drives emphysema in smokers, but how these cells are elicited remains unknown. A study now links the microRNA miR-22 and the histone deacetylase HDAC4 to regulation of the activation of antigen-presenting cells after exposure to smoke.
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References
Lozano, R. et al. Lancet 380, 2095–2128 (2012).
Lu, W. et al. Nat. Immunol. 16, 1185–1194 (2015).
Brusselle, G.G., Joos, G.F. & Bracke, K.R. Lancet 378, 1015–1026 (2011).
Lee, S.H. et al. Nat. Med. 13, 567–569 (2007).
Eustace, A. et al. Chest 139, 1089–1100 (2011).
Roos, A.B. et al. Am. J. Respir. Crit. Care Med. 192, 428–437 (2015).
Loth, D.W. et al. Nat. Genet. 46, 669–677 (2014).
Chen, K. et al. PLoS ONE 6, e20333 (2011).
Roos, A.B. et al. Am. J. Respir. Crit. Care Med. 191, 1232–1241 (2015).
Agusti, A., Sobradillo, P. & Celli, B. Am. J. Respir. Crit. Care Med. 183, 1129–1137 (2011).
Gaffen, S.L. et al. Nat. Rev. Immunol. 14, 585–600 (2014).
Miossec, P. & Kolls, J.K. Nat. Rev. Drug Discov. 11, 763–776 (2012).
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Brusselle, G., Bracke, K. MicroRNA miR-22 drives TH17 responses in emphysema. Nat Immunol 16, 1109–1110 (2015). https://doi.org/10.1038/ni.3295
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DOI: https://doi.org/10.1038/ni.3295
