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Tuning up FALCs: immunological shielding in the body cavities

Fat-associated lymphoid clusters (FALCs) are non-classical secondary lymphoid organs of the body cavities. The formation and maturation of FALCs are driven by tumor-necrosis factor and are further enhanced by invariant natural killer T cells.

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Figure 1: TNFR-independent and TNFR-dependent formation of FALCs.

Marina Corral Spence/Nature Publishing Group

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Correspondence to Burkhard Ludewig.

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Perez-Shibayama, C., Ludewig, B. Tuning up FALCs: immunological shielding in the body cavities. Nat Immunol 16, 796–798 (2015). https://doi.org/10.1038/ni.3228

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