Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis of Francisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.
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Fitzgerald, K., Rathinam, V. GBPs take AIM at Francisella. Nat Immunol 16, 443–444 (2015). https://doi.org/10.1038/ni.3144
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DOI: https://doi.org/10.1038/ni.3144
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