Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

GBPs take AIM at Francisella

Guanylate-binding proteins (GBPs) induced by type I interferon signaling cause lysis of Francisella bacteria that have reached the host-cell cytosol. The liberated bacterial DNA is then sensed by the cytosolic AIM2 inflammasome, which activates caspase-1 and leads to pyroptotic cell death.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Rent or buy this article

Prices vary by article type

from$1.95

to$39.95

Prices may be subject to local taxes which are calculated during checkout

Figure 1: IRF1 and GBPs facilitate the release of bacterial DNA into the host cytosol.

Katie Vicari/Nature Publishing Group

References

  1. Man et al. Nat. Immunol. 16, 467–475 (2015).

    Article  CAS  Google Scholar 

  2. Meunier, E. et al. Nat. Immunol. 16, 476–484 (2015).

    Article  CAS  Google Scholar 

  3. Rathinam, V.A.K. et al. Nat. Immunol. 11, 395–402 (2010).

    Article  CAS  Google Scholar 

  4. Jones, J.W. et al. Proc. Natl. Acad. Sci. USA 107, 9771–9776 (2010).

    Article  CAS  Google Scholar 

  5. Fernandes-Alnemri, T. et al. Nat. Immunol. 11, 385–393 (2010).

    Article  CAS  Google Scholar 

  6. Kim, B.-H. et al. Science 332, 717–721 (2011).

    Article  CAS  Google Scholar 

  7. Yamamoto, M. et al. Immunity 37, 302–313 (2012).

    Article  CAS  Google Scholar 

  8. Meunier, E. et al. Nature 509, 366–370 (2014).

    Article  CAS  Google Scholar 

  9. Pilla, D.M. et al. Proc. Natl. Acad. Sci. USA 111, 6046–6051 (2014).

    Article  CAS  Google Scholar 

  10. Rathinam, V.A.K. et al. Cell 150, 606–619 (2012).

    Article  CAS  Google Scholar 

  11. Storek, K.M., Gertsvolf, N.A., Ohlson, M.B. & Monack, D.M. J. Immunol. 194, 3236–3245 (2015).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Vijay A K Rathinam.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Fitzgerald, K., Rathinam, V. GBPs take AIM at Francisella. Nat Immunol 16, 443–444 (2015). https://doi.org/10.1038/ni.3144

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.3144

This article is cited by

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing