The transcription factor Sox2 has an additional function in neutrophils, as a cytoplasmic sensor of DNA. Upon binding bacterial DNA, Sox2 initiates a signaling cascade dependent on the kinase TAK1 and adaptor TAB2 that culminates in the expression of genes encoding pro-inflammatory molecules.
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Mankan, A., Hornung, V. Sox2 as a servant of two masters. Nat Immunol 16, 335–336 (2015). https://doi.org/10.1038/ni.3121
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DOI: https://doi.org/10.1038/ni.3121
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