Skip to main content

Thank you for visiting nature.com. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser (or turn off compatibility mode in Internet Explorer). In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript.

  • News & Views
  • Published:

A new VEGF connection between two old neighbors

Plasmacytoid dendritic cells express the microRNA miR-126, which controls their survival and effector functions via the receptor VEGFR2.

This is a preview of subscription content, access via your institution

Access options

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Figure 1: A model for miR-126-orchestrated regulation of pDC effector functions in lymph nodes undergoing an immune response.

Marina Corral Spence

References

  1. Colonna, M., Trinchieri, G. & Liu, Y.J. Nat. Immunol. 5, 1219–1226 (2004).

    Article  CAS  Google Scholar 

  2. Agudo, J. et al. Nat. Immunol. 15, 54–62 (2014).

    Article  CAS  Google Scholar 

  3. Fish, J.E. & Srivastava, D. Sci. Signal. 2, pe1 (2009).

    Article  Google Scholar 

  4. Lodish, H.F., Zhou, B., Liu, G. & Chen, C.Z. Nat. Rev. Immunol. 8, 120–130 (2008).

    Article  CAS  Google Scholar 

  5. Banchereau, J. & Steinman, R.M. Nature 392, 245–252 (1998).

    CAS  Google Scholar 

  6. Kuipers, H., Schnorfeil, F.M. & Brocker, T. Mol. Immunol. 48, 333–340 (2010).

    Article  CAS  Google Scholar 

  7. Coultas, L., Chawengsaksophak, K. & Rossant, J. Nature 438, 937–945 (2005).

    Article  CAS  Google Scholar 

  8. Facchetti, F. et al. Immunol. Lett. 20, 277–281 (1989).

    Article  CAS  Google Scholar 

  9. Webster, B. et al. J. Exp. Med. 203, 1903–1913 (2006).

    Article  CAS  Google Scholar 

  10. Labidi-Galy, S.I. et al. OncoImmunology 1, 380–382 (2012).

    Article  Google Scholar 

  11. Vermi, W. et al. J. Pathol. 200, 255–268 (2003).

    Article  Google Scholar 

  12. Curiel, T.J. et al. Cancer Res. 64, 5535–5538 (2004).

    Article  CAS  Google Scholar 

  13. Zhou, H. et al. Blood 116, 5885–5894 (2010).

    Article  CAS  Google Scholar 

  14. Karrich, J.J. et al. Blood 122, 3001–3009 (2013).

    Article  CAS  Google Scholar 

  15. Hong, Y. et al. PLoS ONE 8, e69926 (2013).

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Marina Cella.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Cella, M., Trinchieri, G. A new VEGF connection between two old neighbors. Nat Immunol 15, 8–9 (2014). https://doi.org/10.1038/ni.2786

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1038/ni.2786

Search

Quick links

Nature Briefing

Sign up for the Nature Briefing newsletter — what matters in science, free to your inbox daily.

Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing