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Influenza vaccines: mTOR inhibition surprisingly leads to protection

Nature Immunology volume 14, pages 1205–1207 (2013)Cite this article

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Mice immunized with influenza virus in the presence of rapamycin, which blocks the formation of germinal centers, make mostly IgM antibodies that protect against infection with multiple subtypes of influenza virus, including avian viruses.

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Figure 1: Rapamycin enhances IgM responses.

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Authors and Affiliations

  1. Andrew J. McMichael is with the Nuffield Department of Medicine, University of Oxford, Oxford, UK.,

    Andrew J McMichael

  2. Barton F. Haynes is with the Department of Medicine, Human Vaccine Institute, Duke University, Durham, North Carolina, USA.,

    Barton F Haynes

Authors
  1. Andrew J McMichael
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  2. Barton F Haynes
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Correspondence to Andrew J McMichael.

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The authors declare no competing financial interests.

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McMichael, A., Haynes, B. Influenza vaccines: mTOR inhibition surprisingly leads to protection. Nat Immunol 14, 1205–1207 (2013). https://doi.org/10.1038/ni.2764

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