Signaling via the interleukin 1 (IL-1) family, particularly by IL-1β, has long been linked to the pathogenesis of atherosclerosis. Findings that atherogenic fatty acids induce IL-1α to promote vascular inflammation identify a key role for this less-well-studied cytokine.
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Sheedy, F., Moore, K. IL-1 signaling in atherosclerosis: sibling rivalry. Nat Immunol 14, 1030–1032 (2013). https://doi.org/10.1038/ni.2711
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DOI: https://doi.org/10.1038/ni.2711
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