Small phosphorylated prenyl metabolites are potent activators of γδ T cells in human peripheral blood, but the molecular mechanism underlying their antigenic potency has remained a mystery. New data identify BTN3A1 as a novel antigen-presentation molecule for both microbial and host-derived phosphorylated antigens.
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Willcox, C., Mohammed, F. & Willcox, B. Resolving the mystery of pyrophosphate antigen presentation. Nat Immunol 14, 886–887 (2013). https://doi.org/10.1038/ni.2689
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DOI: https://doi.org/10.1038/ni.2689
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