Members of the SOCS (suppressor of cytokine signaling) family negatively regulate STAT transcription factors. The SOCS family member CIS is now shown to negatively regulate differentiation into the TH2 and TH9 subsets of helper T cells through negative regulation of STAT3, STAT5 and STAT6.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Yoshimura, A., Naka, T. & Kubo, M. Nat. Rev. Immunol. 7, 454–465 (2007).
Kubo, M., Hanada, T. & Yoshimura, A. Nat. Immunol. 4, 1169–1176 (2003).
Matsumoto, A. et al. Mol. Cell Biol. 19, 6396–6407 (1999).
Aman, M.J. et al. J. Biol. Chem. 274, 30266–30272 (1999).
Li, S. et al. J. Exp. Med. 191, 985–994 (2000).
Miah, M.A. et al. Eur. J. Immunol. 42, 58–68 (2012).
Khor, C.C. et al. N. Engl. J. Med. 362, 2092–2101 (2010).
Yang, X.O. Nat. Immunol. 14, 732–740 (2013).
Babon, J.J. et al. Immunity 36, 239–250 (2012).
Yoshimura, A. et al. EMBO J. 14, 2816–2826 (1995).
Kaplan, M.H. Immunol. Rev. 252, 104–115 (2013).
Tamiya, T., Kashiwagi, I., Takahashi, R., Yasukawa, H. & Yoshimura, A. Arterioscler. Thromb. Vasc. Biol. 31, 980–985 (2011).
Rascle, A. & Lees, E. Nucleic Acids Res. 31, 6882–6890 (2003).
Wilhelm, C., Turner, J.E., Van Snick, J. & Stockinger, B. Nat. Immunol. 13, 637–641 (2012).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The author declares no competing financial interests.
Rights and permissions
About this article
Cite this article
Yoshimura, A. CIS: the late-blooming eldest son. Nat Immunol 14, 692–694 (2013). https://doi.org/10.1038/ni.2645
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.2645
