The newly identified steroid ligand of the receptor EBI2 (GPCR183), 7α,25-dihydroxycholesterol, is required for the positioning of splenic CD4+ dendritic cells in bridging channels to prime T cells for an efficient antibody response.
This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
Modulation of immunological responses by aqueous extract of Datura stramonium L. seeds on cyclophosphamide-induced immunosuppression in Wistar rats
BMC Immunology Open Access 19 October 2022
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Gatto, D. et al. Nat. Immunol. 14, 446–453 (2013).
Yi, T. et al. Immunity 37, 535–548 (2012).
Pereira, J.P., Kelly, L.M., Xu, Y. & Cyster, J.G. Nature 460, 1122–1126 (2009).
Gatto, D., Paus, D., Basten, A., Mackay, C.R. & Brink, R. Immunity 31, 259–269 (2009).
Chappell, C.P., Draves, K.E., Giltiay, N.V. & Clark, E.A. J. Exp. Med. 209, 1825–1840 (2012).
Czeloth, N. et al. J. Immunol. 179, 5855–5863 (2007).
Kabashima, K. et al. Immunity 22, 439–450 (2005).
Naik, S.H. et al. Nat. Immunol. 7, 663–671 (2006).
Gatto, D., Wood, K. & Brink, R. J. Immunol. 187, 4621–4628 (2011).
Cinamon, G. et al. Nat. Immunol. 5, 713–720 (2004).
Arnon, T.I., Horton, R.M., Grigorova, I.L. & Cyster, J.G. Nature 493, 684–688 (2013).
Thelen, M. & Stein, J.V. Nat. Immunol. 9, 953–959 (2008).
Author information
Authors and Affiliations
Corresponding authors
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Rights and permissions
About this article
Cite this article
Jarrossay, D., Thelen, M. Immune response: steroids drive dendritic cells. Nat Immunol 14, 424–426 (2013). https://doi.org/10.1038/ni.2589
Published:
Issue Date:
DOI: https://doi.org/10.1038/ni.2589
