Severe intestinal pathology associated with infection with Toxoplasma gondii is a result of the loss of Paneth cells, an unexpected side effect of the secretion of IFN-γ by protective CD4+ T cells in the intestinal mucosa.
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McSorley, S., Bevins, C. Paneth cells: targets of friendly fire. Nat Immunol 14, 114–116 (2013). https://doi.org/10.1038/ni.2519
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DOI: https://doi.org/10.1038/ni.2519