The secretion of cytokines by helper T cells is affected by the cytokine environment and by costimulatory signals. Engagement of the receptor OX40 on T cells increases expression of the transcription factor TRAF6, activates the alternative transcription factor NF-κB pathway and induces the production of interleukin 9.
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Debbie Maizels
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Goswami, R., Kaplan, M. Yoking OX40 to regulation of IL-9. Nat Immunol 13, 942–943 (2012). https://doi.org/10.1038/ni.2421
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DOI: https://doi.org/10.1038/ni.2421
