Immunosurveillance monitors subversion of the endoplasmic reticulum aminopeptidase ERAAP. ERAAP-deficient cells are killed by T cells that recognize nonclassical major histocompatibility complex class I Qa-1 molecules presenting peptides generated in the absence of ERAAP.
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Yewdell, J., Lu, X. Don't mess with ERAAP!. Nat Immunol 13, 526–528 (2012). https://doi.org/10.1038/ni.2306
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DOI: https://doi.org/10.1038/ni.2306
