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Lipids-Я-Us: peroxisome generation of iNKT ligands

The identification of the natural lipids that select invariant natural killer T cells (iNKT cells) in vivo has been somewhat elusive and controversial. A new study shows that ether-bonded phospholipids, generated mainly in peroxisomes, are responsible for the development of a major subpopulation of iNKT cells.

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Figure 1: Deficiency in GNPAT results in a defect in iNKT cell development.

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Correspondence to Randy R Brutkiewicz.

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Brutkiewicz, R., Dent, A. Lipids-Я-Us: peroxisome generation of iNKT ligands. Nat Immunol 13, 435–436 (2012). https://doi.org/10.1038/ni.2288

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