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Inflammasomes: far beyond inflammation

Nature Immunology volume 13, pages 321–324 (2012)Cite this article

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Nearly a decade ago, the concept of inflammasomes was introduced. Since then, the biochemical characterization of the inflammasomes has led to a richer understanding of innate immune responses in the context of infection and sterile inflammation. This has provided the rationale for successful clinical therapies for a spectrum of hereditary periodic fever syndromes and potentially for some metabolic pathologies.

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Figure 1: Inflammasome activity regulates homeostatic processes and inflammation during infection and tissue injury.

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Acknowledgements

We thank F. Manzo for technical assistance. Supported by the Cancer Research Institute (E.E.), the Israel-US Educational Foundation (E.E.), the American Physicians for Medicine in Israel Foundation (E.E.), the Leukemia and Lymphoma Society (J.H.-M. and T.S.), the United States-Israel Binational Foundation (E.E. and R.A.F.) and the Howard Hughes Medical Institute (R.A.F.).

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Authors and Affiliations

  1. Till Strowig and Richard A. Flavell are in the Department of Immunobiology, Jorge Henao-Mejia, Eran Elinav, Yale University School of Medicine, New Haven, Connecticut, USA,

    Jorge Henao-Mejia, Eran Elinav, Till Strowig & Richard A Flavell

  2. Richard A. Flavell is with the Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, Connecticut, USA.,

    Richard A Flavell

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  1. Jorge Henao-Mejia
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  2. Eran Elinav
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Correspondence to Richard A Flavell.

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Henao-Mejia, J., Elinav, E., Strowig, T. et al. Inflammasomes: far beyond inflammation. Nat Immunol 13, 321–324 (2012). https://doi.org/10.1038/ni.2257

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