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Failure to detect production of IL-10 by activated human neutrophils

Nature Immunology volume 12, pages 1017–1018 (2011)Cite this article

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To the Editor:

We read with great interest the paper by De Santo et al.1 published in the November 2010 issue of Nature Immunology, which has received wide attention because of its potential implications for inflammation and immunotherapy. The authors show that the acute-phase protein serum amyloid A1 (SAA-1) induces substantial secretion of the immunosuppressive cytokine interleukin 10 (IL-10) by human neutrophils (up to 100–400 ng/ml) and that invariant natural killer T cells (iNKT cells) are able to diminish this. The authors conclude that harnessing iNKT cells might “be useful therapeutically by decreasing the frequency of immunosuppressive neutrophils and restoring tumor-specific immune responses” in patients with melanoma and other patients with high plasma SAA-1 concentrations1.

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Figure 1: Lack of IL-10 production by SAA-1- or LPS-stimulated human neutrophils.

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Author notes

  1. Martin S Davey and Nicola Tamassia: These authors contributed equally to this work.

Authors and Affiliations

  1. Department of Infection, Immunity and Biochemistry, School of Medicine, Cardiff University, Cardiff, UK

    Martin S Davey, Bernhard Moser & Matthias Eberl

  2. Department of Pathology and Diagnostics, Division of General Pathology, University of Verona, Verona, Italy

    Nicola Tamassia, Marzia Rossato, Flavia Bazzoni, Federica Calzetti & Marco A Cassatella

  3. Department of Otorhinolaryngology, University Hospital Essen, Essen, Germany

    Kirsten Bruderek & Sven Brandau

  4. Istituto Clinico Humanitas Istituto di Ricovero e Cura a Carattere Scientifico and University of Milan, Milan, Italy

    Marina Sironi, Barbara Bottazzi & Alberto Mantovani

  5. Department of Dermatology, University Hospital Essen, Essen, Germany

    Lisa Zimmer

Authors
  1. Martin S Davey
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Corresponding authors

Correspondence to Matthias Eberl or Marco A Cassatella.

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Davey, M., Tamassia, N., Rossato, M. et al. Failure to detect production of IL-10 by activated human neutrophils. Nat Immunol 12, 1017–1018 (2011). https://doi.org/10.1038/ni.2111

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