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Bridging the information gap

The interaction between hematopoietic stem cells and their niche is critical for the lifelong maintenance of the blood system. New research shows that crosstalk between stromal components of the niche mediates secretion of the chemokine CXCL12.

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Figure 1: A model of how communication between BMSCs mediated by connexin gap junctions may affect the HSC-supportive function of the niche.

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Correspondence to Andreas Trumpp.

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Milsom, M., Trumpp, A. Bridging the information gap. Nat Immunol 12, 377–379 (2011). https://doi.org/10.1038/ni.2026

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