In addition to their classical function in antigen presentation and their lesser known ability to act as signal transducers, major histocompatibility complex class II molecules are now shown to promote Toll-like receptor signaling. This intriguing role requires intracellular association with the kinase Btk and the costimulatory molecule CD40.
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Hassan, G., Mourad, W. An unexpected role for MHC class II. Nat Immunol 12, 375–376 (2011). https://doi.org/10.1038/ni.2023
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DOI: https://doi.org/10.1038/ni.2023
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