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Admixture mapping for hypertension loci with genome-scan markers

Nature Genetics 37, 177–181 (2005) | Download Citation

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Abstract

Identification of genetic variants that contribute to risk of hypertension is challenging. As a complement to linkage and candidate gene association studies, we carried out admixture mapping using genome-scan microsatellite markers among the African American participants in the US National Heart, Lung, and Blood Institute's Family Blood Pressure Program. This population was assumed to have experienced recent admixture from ancestral groups originating in Africa and Europe. We used a set of unrelated individuals from Nigeria to represent the African ancestral population and used the European Americans in the Family Blood Pressure Program to provide estimates of allele frequencies for the European ancestors. We genotyped a common set of 269 microsatellite markers in the three groups at the same laboratory. The distribution of marker location–specific African ancestry, based on multipoint analysis, was shifted upward in hypertensive cases versus normotensive controls, consistent with linkage to genes conferring susceptibility. This shift was largely due to a small number of loci, including five adjacent markers on chromosome 6q and two on chromosome 21q. These results suggest that chromosome 6q24 and 21q21 may contain genes influencing risk of hypertension in African Americans.

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Acknowledgements

We thank D. Kan for his assistance in programming. This work was supported by grants awarded to the Family Blood Pressure Program, which is supported by a series of cooperative agreements from the National Heart, Lung and Blood Institute to GenNet, HyperGEN, GENOA and SAPPHIRe. The work was also supported by the Reynolds Cardiovascular Clinical Research Center at the University of Texas Southwestern, Dallas, Texas, USA. Genotype data for the Nigerian samples are available on request from R.S.C. (rcooper@lumc.edu).

Author information

Affiliations

  1. Department of Preventive Medicine and Epidemiology, Loyola University Medical Center, 2160 S. First Ave., Maywood, Illinois 60153, USA.

    • Xiaofeng Zhu
    • , Amy Luke
    •  & Richard S Cooper

  2. Division of Cardiovascular Medicine, Stanford University School of Medicine, Stanford, California, USA.

    • Tom Quertermous

  3. Department of Genetics, University of Texas, Houston, Texas, USA.

    • Craig Hanis

  4. Department of Medicine (Geriatrics), University of Mississippi Medical Center, Jackson, Mississippi, USA.

    • Tom Mosley

  5. Division of Biostatistics, Washington University, St. Louis, Missouri, USA.

    • C Charles Gu
    •  & Dabeeru C Rao

  6. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

    • Hua Tang

  7. Department of Genetics, Stanford University School of Medicine, Stanford, California 94305-5120, USA.

    • Neil Risch

  8. Division of Research, Kaiser Permanente, Oakland, California, USA.

    • Neil Risch

  9. Department of Medicine, University of Michigan Medical School, Ann Arbor, Michigan, USA.

    • Alan Weder

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Competing interests

The authors declare no competing financial interests.

Corresponding author

Correspondence to Neil Risch.

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    Supplementary Table 1

    Results of logistic regression of hypertension on marker location-specific African ancestry after adjusting for sex, age and body mass index.

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DOI

https://doi.org/10.1038/ng1510

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