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Two sides of the same coin

Dramatically different mutant phenotypes usually reflect mutations in different genes, but this is not necessarily so, especially when microRNA regulation is involved. A beautiful example of this now comes from the discovery of the maize microRNA tasselseed4 and its target ids1/Tasselseed6, which uncovers a new facet in the control of inflorescence branching and sex determination in flowers.

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Figure 1: The ts4 locus encodes a microRNA, miR172, that targets ids1.

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Gallavotti, A., Schmidt, R. Two sides of the same coin. Nat Genet 39, 1425–1426 (2007). https://doi.org/10.1038/ng1207-1425

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