The protein tyrosine phosphatase PTPN22 (also called LYP) is the leading example of a genetic variant that confers risk of developing diverse human autoimmune diseases, including type 1 diabetes, rheumatoid arthritis, autoimmune thyroid disease and systemic lupus. A new study now shows that the PTPN22 risk-associated variant, Trp620, results in a gain of PTPN22 phosphatase activity in T cells, opening up new avenues for exploring disease mechanisms.
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Gregersen, P. Gaining insight into PTPN22 and autoimmunity. Nat Genet 37, 1300–1302 (2005). https://doi.org/10.1038/ng1205-1300
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DOI: https://doi.org/10.1038/ng1205-1300
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