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Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice

Nature Genetics volume 11, pages 150–154 (1995)Cite this article

Abstract

Airway hyperresponsiveness is a key characteristic of human asthma and a marker for asthma–like conditions in animals. F1 mice derived from A/J and C57BL/6J display a phenotype which resembles the asthma–like phenotype of the A/J mice. Since airway responsiveness failed to segregate as a mendelian trait, we show significant linkage at two loci, Bhr1 (lod = 3.0) and Bhr2 (lod = 3.7) on chromosomes 2 and 15. A third locus, Bhr3 (lod = 2.83), maps to chromosome 17. Each of these loci maps near candidate loci implicated in the pathobiology of asthma. Our study represents the first linkages established through a genome–wide survey of airway hyperresponsiveness in any mammal.

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Authors and Affiliations

  1. Combined Program in Pulmonary and Critical Care Medicine, Brigham & Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115, USA

    George T. De Sanctis, James K. Grobholz & Jeffrey M. Drazen

  2. Whitehead Institute/MIT Center for Genome Research, Whitehead Institute for Biomedical Research, 9 Cambridge Center, Cambridge, Massachusetts, 02142, USA

    Mark Merchant, Robert D. Dredge & Eric S. Lander

  3. Genetics Division, Brigham & Women's Hospital and Harvard Medical School, 75 Francis Street, Boston, Massachusetts, 02115, USA

    David R. Beier

  4. Department of Pediatrics, Children's Hospital, 300 Longwood Ave, Boston, Massachusetts, 02115, USA

    Thomas R. Martin

  5. Department of Biology, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Eric S. Lander

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  1. George T. De Sanctis
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De Sanctis, G., Merchant, M., Beier, D. et al. Quantitative locus analysis of airway hyperresponsiveness in A/J and C57BL/6J mice. Nat Genet 11, 150–154 (1995). https://doi.org/10.1038/ng1095-150

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