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Normal long bone growth and development in type X collagen-null mice

Nature Genetics volume 8, pages 129–135 (1994)Cite this article

Abstract

To investigate the role of type X collagen in skeletal development, we have generated type X collagen-null mice. Surprisingly, mice without type X collagen were viable and fertile and had no gross abnormalities in long bone growth or development. No differences were detected between the type X collagen-null mice and controls when growth plates of both newborn and 3-week old mice were examined by histology and by immunostaining for extracellular matrix components of bone including osteopontin, osteocalcin and type II collagen. Our results suggest that type X collagen is not required for long bone development. However, mice and humans with dominant acting type X collagen mutations have bone abnormalities, suggesting that only the presence of abnormal type X collagen can modify bone growth and development.

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Authors and Affiliations

  1. Department of Molecular Genetics, The University of Texas M. D. Anderson Cancer Center, Houston, Texas, 77030, USA

    Rita Rosati, Gerald S. B. Horan, Silvio Garofalo, Benoit de Crombrugghe & Richard R. Behringer

  2. Istituto per lo Studio a la Cura dei Tumori, Fondazione G. Pascale, Naples, Italy

    Rita Rosati

  3. Department of Basic Sciences, Dental Branch, The University of Texas Houston Health Science Center, Houston, Texas, 77030, USA

    Gerald J. Pinero

  4. Shriner's Hospital, 3101 S.W. Sam Jackson Park Rd., Portland, Oregon, 97201, USA

    Douglas R. Keene & William A. Horton

  5. Department of Molecular Biology and Medical Biochemistry, The University of Turku, Turku, Finland

    Eero Vuorio

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Rosati, R., Horan, G., Pinero, G. et al. Normal long bone growth and development in type X collagen-null mice. Nat Genet 8, 129–135 (1994). https://doi.org/10.1038/ng1094-129

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