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The genetics of health

Nature Genetics volume 38, pages 1095–1098 (2006)Cite this article

Recent experience with several high-profile drugs demonstrates the great challenges in developing effective and safe therapeutics. A complementary approach to the popular paradigm of disease genetics is based on inherited factors that reduce the incidence and severity of disease among individuals who are genetically predisposed to disease. We propose testing specifically for modifier genes and protective alleles among at-risk individuals and studying the efficacy of therapeutics based on the genetics of health.

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Acknowledgements

We acknowledge the support of US National Institutes of Health grants P40 RR12305 and RO1 CA75056 to J.H.N. and P50 HL077101 to E.J.T.

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Authors and Affiliations

  1. Department of Genetics, Case Western Reserve University School of Medicine, 2109 Adelbert Road, Cleveland, 44106, Ohio, USA

    Joseph H Nadeau & Eric J Topol

  2. Joseph H Nadeau & Eric J Topol

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  1. Joseph H Nadeau
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  2. Eric J Topol
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Nadeau, J., Topol, E. The genetics of health. Nat Genet 38, 1095–1098 (2006). https://doi.org/10.1038/ng1006-1095

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