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Many hypotheses but no replication for the association between PDE4D and stroke

Nature Genetics volume 38, pages 1091–1092 (2006)Cite this article

To the Editor:

Stroke is the second-leading cause of death and a major cause of long-term disability throughout the world. Accumulated evidence suggests that inherited genetic variation plays a role in its pathogenesis. The need for identifying culprit genetic variants is great, since they may provide novel targets for the preventative therapeutics that are desperately needed.

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Figure 1: Pairwise r2 plot for 11 associated SNPs and allele 0 of microsatellite AC008818-1 in the HapMap CEU panel.

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Author information

Authors and Affiliations

  1. Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA

    Jonathan Rosand & Natalia Rost

  2. Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA

    Jonathan Rosand, Nick Bayley, Natalia Rost & Paul I W de Bakker

  3. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, 02142, Massachusetts, USA

    Jonathan Rosand, Nick Bayley, Natalia Rost & Paul I W de Bakker

Authors
  1. Jonathan Rosand
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  2. Nick Bayley
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  3. Natalia Rost
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  4. Paul I W de Bakker
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Supplementary information

Supplementary Fig. 1

Risk estimates for combined cardiogenic and large-vessel stroke. (PDF 20 kb)

Supplementary Table 1

Alleles associated in individual studies. (PDF 83 kb)

Supplementary Table 2

Summary of pairwise LD statistics in HapMap CEU. (PDF 36 kb)

Supplementary Table 3

Novel hypotheses regarding the role of PDE4D in stroke raised by each study. (PDF 62 kb)

Supplementary Methods (PDF 48 kb)

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Rosand, J., Bayley, N., Rost, N. et al. Many hypotheses but no replication for the association between PDE4D and stroke. Nat Genet 38, 1091–1092 (2006). https://doi.org/10.1038/ng1006-1091

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