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Genetics of common polygenic stroke

Nature Genetics volume 35, pages 116–117 (2003)Cite this article

Ischemic stroke is a late-onset, complex polygenic disease, and it has proven difficult to identify its genetic determinants. A new study from Iceland shows that the gene encoding phosphodiesterase 4D is the most likely positional and pathophysiological candidate underlying the stroke susceptibility locus on chromosome 5q12.

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Figure 1: A theoretical scenario to illustrate multiple interactions between genetic and environmental factors in the outcome of a phenotype such as stroke.

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Authors and Affiliations

  1. Division of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Western Infirmary, Glasgow, G11 6NT, UK

    Anna F Dominiczak & Martin W McBride

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  1. Anna F Dominiczak
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  2. Martin W McBride
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Dominiczak, A., McBride, M. Genetics of common polygenic stroke. Nat Genet 35, 116–117 (2003). https://doi.org/10.1038/ng1003-116

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