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Intra-cytoplasmic sperm injection and infertility

Nature Genetics volume 29, page 131 (2001) | Download Citation



Assisted reproductive technology has revolutionized the treatment of infertility, one of the most common disorders of human health. From the breakthrough of in vitro fertilization to the advent of reproductive cloning, each milestone has been accompanied by controversy over the implications for both society and the child-to-be. ICSI is no exception, as this technology now gives virtually all men with severe oligospermia or azoospermia the chance to become a genetic parent1. Extremely low sperm counts are thought to be of primarily genetic origin, caused by such factors as microdeletions in the AZFc region on the Y chromosome. With the advent of ICSI, 'sterile' men can now father children who, in turn, inherit their genetic defects2,3.

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Author information


  1. School of Mathematics & Statistics, The University of Birmingham, Edgbaston, UK.

    • Malcolm J. Faddy
  2. Infertility Center of St. Louis, St. Luke's Hospital, St. Louis, Missouri, USA.

    • Sherman J. Silber
  3. Department of Obstetrics & Gynecology, McGill University, Montreal Quebec, H3A 1A1, Canada.

    • Roger G. Gosden


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Correspondence to Roger G. Gosden.

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