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Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

Nature Genetics volume 5, pages 95–100 (1993)Cite this article

Abstract

Familial Alzheimer's disease (FAD) is a genetically heterogeneous disorder that includes a rare early–onset form linked to mutations in the amyloid b protein precursor (APP) gene. Clues to the function of APP derive from the recent finding that it is a member of a highly conserved protein family that includes the mammalian amyloid recursor–like protein (APLP1) gene which maps to the same general region of human chromosome 19 linked to late–onset FAD. Here we report the isolation of the human APLP2 gene. We show that APLP2 is a close relative of APP and exhibits a very similar pattern of expression in the brain and throughout the body. Like APP, APLP2 contains a cytoplasmic domain predicted to couple with the GTP–binding protein Go indicating that it may be an additional cell surface activator of this G protein.

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Author information

Authors and Affiliations

  1. Laboratory of Genetics and Aging, Neuroscience Center, Massachusetts General Hospital, Charlestown, Massachusetts, 02129, USA

    Wilma Wasco, Sarada Gurubhagavatula, Marc d. Paradis, Donna M. Romano & Rudolph E. Tanzi

  2. Department of Pathology and the Neuropathology Laboratory, The Johns Hopkins University School of Medicine, Baltimore, Maryland, 21205-2181, USA

    Sangram S. Sisodia

  3. Department of Neurology, Massachusetts General Hospital, Boston, Massachusetts, 02115, USA

    Bradley T. Hyman

  4. Mailman Research Center, McLean Hospital, Belmont, Massachusetts, 02178, USA

    Rachael L. Neve

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  1. Wilma Wasco
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Wasco, W., Gurubhagavatula, S., Paradis, M. et al. Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor. Nat Genet 5, 95–100 (1993). https://doi.org/10.1038/ng0993-95

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