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Genetic dissection of autoimmune type I diabetes in the BB rat

Nature Genetics volume 2, pages 56–60 (1992)Cite this article

A Correction to this article was published on 01 June 1994

Abstract

The BB rat is among the best models of insulin–dependent diabetes mellitus — with onset and pathogenesis closely resembling the human disease. One unusual feature is a severe T–cell lymphopenia, which appears to be inherited as a recessive trait controlled by a single gene, Lyp. Based on genetic analysis of several crosses, we show that development of diabetes involves at least three genes: Lyp, which is tightly linked to the neuropeptide Y (Npy) gene on chromosome 4, a gene linked to the major histocompatibility complex (MHC) on chromosome 20, and a third unmapped gene for which the Fischer rat strain carries an allele conferring resistance.

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Authors and Affiliations

  1. Whitehead Institute for Biomedical Research, Cambridge, Massachusetts, 02142, USA

    Howard J. Jacob, Yipei Mao & Eric S. Lander

  2. Department of Biology and Center for Genome Research, Massachusetts Institute of Technology, Cambridge, Massachusetts, 02139, USA

    Howard J. Jacob, Yipei Mao & Eric S. Lander

  3. Department of Medicine, RG-20, University of Washington, Seattle, Washington, 98195, USA

    Anna Pettersson, Deborah Wilson & Åke Lernmark

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  1. Howard J. Jacob
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  2. Anna Pettersson
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  3. Deborah Wilson
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  4. Yipei Mao
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  5. Åke Lernmark
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  6. Eric S. Lander
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Jacob, H., Pettersson, A., Wilson, D. et al. Genetic dissection of autoimmune type I diabetes in the BB rat. Nat Genet 2, 56–60 (1992). https://doi.org/10.1038/ng0992-56

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