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Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice

Nature Genetics volume 10, pages 466–471 (1995)Cite this article

Abstract

We report the unprecedented finding of a gene with a different map position in two mouse strains. The Clcn4 gene was found to map to the X chromosome in the wild Mediterrean mouse, Mus spretus but to chromosome 7 in the inbred strain of laboratory mouse C57BL/6J. These data indicate that a recent evolutionary rearrangement occurred on the mouse sex chromosomes, very close to the pseudoautosomal region. Our data provide molecular evidence for a major divergence near the pseudoautosomal region, consistent with the hypothesis that hybrid sterility in these species results from abnormal pairing of sex chromosomes during male meiosis.

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Authors and Affiliations

  1. Telethon Institute of Genetics and Medicine (TIGEM), San Raffaele Biomedical Science Park, Milano, Italy

    Elena I. Rugarli, Giuseppe Borsani, Brunella Franco & Andrea Ballabio

  2. Department of Pathology, University of Washington, Seattle, Washington, 98195, USA

    David A. Adler, Karen Tsuchiya & Christine Disteche

  3. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, Texas, 77030, USA

    Xueya Hauge

  4. Department of Molecular and Cell Biology, Roswell Park Cancer Institute, Buffalo, New York, 14263, USA

    Verne Chapman

  5. Department of Molecular Biology, University of Siena, Siena, Italy

    Andrea Ballabio

Authors
  1. Elena I. Rugarli
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  2. David A. Adler
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  7. Christine Disteche
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  8. Verne Chapman
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  9. Andrea Ballabio
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Rugarli, E., Adler, D., Borsani, G. et al. Different chromosomal localization of the Clcn4 gene in Mus spretus and C57BL/6J mice. Nat Genet 10, 466–471 (1995). https://doi.org/10.1038/ng0895-466

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