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Limits of sequence and functional conservation

Nature Genetics volume 42, pages 557–558 (2010)Cite this article

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Sequence conservation of noncoding DNA across species can indicate functional conservation. However, a new study demonstrates notable differences between human and mouse stem cell regulatory networks, suggesting caution in generalizing from sequence to functional conservation.

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Figure 1: Conservation and rewiring of regulatory elements between human and mouse genomes.

References

  1. Kunarso, G. et al. Nat. Genet. 42, 631–634 (2010).

    Article  CAS  Google Scholar 

  2. Cooper, G.M. & Brown, C.D. Genome Res. 18, 201–205 (2008).

    Article  CAS  Google Scholar 

  3. King, D.C. et al. Genome Res. 15, 1051–1060 (2005).

    Article  CAS  Google Scholar 

  4. Visel, A. et al. Nature 457, 854–858 (2009).

    Article  CAS  Google Scholar 

  5. ENCODE Project Consortium et al. Nature 447, 799–816 (2007).

  6. Bourque, G. et al. Genome Res. 18, 1752–1762 (2008).

    Article  CAS  Google Scholar 

  7. Wang, T. et al. Proc. Natl. Acad. Sci. USA 104, 18613–18618 (2007).

    Article  CAS  Google Scholar 

  8. Bejerano, G. et al. Nature 441, 87–90 (2006).

    Article  CAS  Google Scholar 

  9. Lowe, C.B., Bejerano, G. & Haussler, D. Proc. Natl. Acad. Sci. USA 104, 8005–8010 (2007).

    Article  CAS  Google Scholar 

  10. Visel, A., Rubin, E.M. & Pennacchio, L.A. Nature 461, 199–205 (2009).

    Article  CAS  Google Scholar 

  11. Xie, D. et al. Genome Res. 20, 804–815 (2010).

    Article  CAS  Google Scholar 

  12. Schmidt, D. et al. Science 328, 1036–1040 (2010).

    Article  CAS  Google Scholar 

Download references

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Authors and Affiliations

  1. Len A. Pennacchio and Axel Visel are at the Genomics Division, Lawrence Berkeley National Laboratory, Berkeley, California, USA.,

    Len A Pennacchio & Axel Visel

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  1. Len A Pennacchio
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  2. Axel Visel
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Correspondence to Len A Pennacchio or Axel Visel.

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The authors declare no competing financial interests.

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Pennacchio, L., Visel, A. Limits of sequence and functional conservation. Nat Genet 42, 557–558 (2010). https://doi.org/10.1038/ng0710-557

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