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PGC-1α at the crossroads of type 2 diabetes

Nature Genetics volume 34, pages 244–245 (2003)Cite this article

Muscle mitochondrial respiratory metabolism is reduced in aging and diabetes. Now, coordinated changes in expression of genes involved in oxidative phosphorylation have been found in individuals with type 2 diabetes mellitus (DM2). Peroxisome proliferator activator protein-γ co-activator-1α (PGC-1α) seems to be in charge of this orchestrated change in gene expression.

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Figure 1: PGC-1α induces expression of mitochondrial respiratory genes and of GLUT4.

Katie Ris

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Authors and Affiliations

  1. Department of Biochemistry,

    Alan D Attie & Christina M Kendziorski

  2. Department of Biostatistics and Medical Informatics at the University of Wisconsin-Madison, Madison, 53706, Wisconsin, USA

    Alan D Attie & Christina M Kendziorski

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  1. Alan D Attie
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  2. Christina M Kendziorski
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Attie, A., Kendziorski, C. PGC-1α at the crossroads of type 2 diabetes. Nat Genet 34, 244–245 (2003). https://doi.org/10.1038/ng0703-244

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