Single-sperm genotyping has provided evidence for hot spots of locally intense recombination in humans. Previous efforts have shown that statistical methods can identify these hot spots as local deficits of linkage disequilibrium, but a report in this issue shows that some recombination hot spots leave no signature of reduced linkage disequilibrium.
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References
Jeffreys, A.J., Kauppi, L. & Neumann, R. Nat. Genet. 29, 217–222 (2001).
Cui, X.F. et al. Proc. Natl. Acad. Sci. USA 86, 9389–9393 (1989).
Jeffreys, A.J., Ritchie, A. & Neumann, R. Hum. Mol. Genet. 9, 725–733 (2000).
Li, N. & Stephens, M. Genetics 165, 2213–2233 (2003).
McVean, G.A. et al. Science 304, 581–584 (2004).
Crawford, D.C. et al. Nat. Genet. 36, 700–706 (2004).
Jeffreys, A.J., Neumann, R., Panayi, M. & Donnelly, P. Nat. Genet. 37, 601–606 (2005).
Yu, J. et al. Am. J. Hum. Genet. 59, 1186–1192 (1996).
Sawyer, S.L. et al. Eur. J. Hum. Genet. 13, 677–686 (2005).
Ohta, T. & Kimura, M. Genetics 68, 571–580 (1971).
Hudson, R.R. Genetics 159, 1805–1817 (2001).
Fearnhead, P., Harding, R.M., Schneider, J.A., Myers, S. & Donnelly P. Genetics 167, 2067–2081 (2004).
Ptak, S.E. et al. Nat. Genet. 37, 429–434 (2005).
Winckler, W. et al. Science 308, 107–111 (2005).
Gerton, J.L. et al. Proc. Natl. Acad. Sci. USA 97, 11383–11390 (2000).
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Clark, A. Hot spots unglued. Nat Genet 37, 563–564 (2005). https://doi.org/10.1038/ng0605-563
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DOI: https://doi.org/10.1038/ng0605-563