A new study shows that a deletion-induced aberrant antisense transcript from a neighboring gene leads to methylation and silencing of the intact gene HBA2 (encoding human α-globin A2) in a family with α-thalassemia. Are there other chromosomal rearrangements that might turn off genes by such antisense-mediated cis-acting methylation?
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Kleinjan, D., van Heyningen, V. Turned off by RNA. Nat Genet 34, 125–126 (2003). https://doi.org/10.1038/ng0603-125
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DOI: https://doi.org/10.1038/ng0603-125
