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Striking sequence similarity over almost 100 kilobases of human and mouse T–cell receptor DNA

Nature Genetics volume 7, pages 48–53 (1994)Cite this article

Abstract

We report here the comparative DNA sequence analysis of nearly 100 kilobases of contiguous DNA in the Cδ to Cα region of the α/δ T cell receptor loci (TCRAC/TCRDC) of mouse and man. This analysis — the largest genomic sequence comparison so far — provides new insights into the functions of the T cell receptor genes as well as the surrounding chromosome structure through the identification of actively conserved DNA sequences. In this comparison we have identified a very high level of organizational and noncoding sequence similarity (∼71%) in contrast to previous findings in the β–globin gene cluster. This observation begins to question the notion that much of the chromosomal non–coding sequence is junk.

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Authors and Affiliations

  1. Department of Biology, Center for Environmental Health, University of Victoria, Victoria, British Columbia, V8W 2Y2, Canada

    Ben F. Koop

  2. Department of Molecular Biotechnology, University of Washington, Seattle, Washington, 98115, USA

    Leroy Hood

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  1. Ben F. Koop
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Koop, B., Hood, L. Striking sequence similarity over almost 100 kilobases of human and mouse T–cell receptor DNA. Nat Genet 7, 48–53 (1994). https://doi.org/10.1038/ng0594-48

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