Epistasis analysis is a foundation in the analysis of genetic networks, but in complex or poorly defined processes, defining the phenotype can be an insurmountable hurdle. A new study shows that microarray expression profiles can be used as a 'phenotype' for epistasis analysis of the development of a multicellular organism, offering a potentially universal solution to this problem.
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References
Bateson, W. Mendel's Principles of Heredity (Cambridge University Press, Cambridge, 1909).
Cairns, B.R., Ramer, S.W. & Kornberg, R.D. Genes Dev. 6, 1305–1318 (1992).
Van Driessche, N. et al. Nat. Genet. 37, 471–477 (2005).
Hughes, T.R. et al. Cell 102, 109–126 (2000).
Liotta, L. & Petricoin, E. Nat. Rev. Genet. 1, 48–56 (2000).
Roberts, C.J. et al. Science 287, 873–880 (2000).
Loomis, W.F. Microbiol. Mol. Biol. Rev. 62, 684–694 (1998).
Harwood, A.J. et al. Dev. Biol. 149, 90–99 (1992).
Zupan, B. et al. Artif. Intell. Med. 29, 107–130 (2003).
Zupan, B. et al. Bioinformatics 19, 383–389 (2003).
Avery, L. & Wasserman, S. Trends Genet. 8, 312–316 (1992).
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Hughes, T. Universal epistasis analysis. Nat Genet 37, 457–458 (2005). https://doi.org/10.1038/ng0505-457
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DOI: https://doi.org/10.1038/ng0505-457