The chromosomes of sperm cells are tightly packaged into a complex of DNA and protamines. Converting the chromatin from a nucleohistone to a nucleoprotamine structure may serve both biophysical and developmental functions. Several recent genetic studies have shown unexpected findings of the dosage requirements for the genes involved in sperm chromatin remodeling.
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Braun, R. Packaging paternal chromosomes with protamine. Nat Genet 28, 10–12 (2001). https://doi.org/10.1038/ng0501-10
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DOI: https://doi.org/10.1038/ng0501-10