Abstract
A total of 116, 118 basepairs (bp) derived from three cosmids spanning the ERCC1 locus of human chromosome 19q13.3 have been sequenced with automated fluorescence-based sequencers and analysed by polymerase chain reaction amplification and computer methods. The assembled sequence forms two contigs totalling 105,831 bp, which contain a human fosB proto-oncogene, a gene encoding a protein phosphatase, two genes of unknown function and the previously-characterized ERCC1 DNA repair gene. This light band region has a high average density of 1.4 Alu repeats per kilobase. Human chromosome light bands could therefore contain up to 75,000 genes and 1.5 million Alu repeats.
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Martin-Gallardo, A., McCombie, W., Gocayne, J. et al. Automated DNA sequencing and analysis of 106 kilobases from human chromosome 19q13.3. Nat Genet 1, 34–39 (1992). https://doi.org/10.1038/ng0492-34
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DOI: https://doi.org/10.1038/ng0492-34
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