Children and young adults with sickle cell anemia at risk for stroke are identified principally by screening for cerebral vasculopathy using transcranial Doppler ultrasonography. Investigators now show how Bayesian networks can generate useful predictive models and highlight relationships between genes and the occurrence of stroke in those with sickle cell anemia.
This is a preview of subscription content, access via your institution
Access options
Subscribe to this journal
Receive 12 print issues and online access
$209.00 per year
only $17.42 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Ohene-Frempong, K. et al. Blood 91, 288–294 (1998).
Driscoll, M.C. et al. Blood 101, 2401–2404 (2003).
Kwiatkowski, J.L. et al. Br. J. Haematol. 121, 932–937 (2003).
Hoppe, C. et al. Blood 103, 2391–2396 (2004).
Adams, G.T. et al. BMC Med. Genet. 4, 6 (2003).
Sebastiani, P. et al. Nat. Genet. 37, 435–440 (2005).
Adams, R. et al. N. Engl. J. Med. 326, 605–610 (1992).
Adams, R.J. et al. Ann. Neurol. 42, 699–704 (1997).
Adams, R.J. et al. N. Engl. J. Med. 339, 5–11 (1998).
Fullerton, H.J. et al. Blood 104, 336–339 (2004).
Adams, R.J. et al. Blood 103, 3689–3694 (2004).
Kral, M.C. et al. Pediatrics 112, 324–331 (2003).
Dhandapani, K.M. & Brann, D.W. Cell Biochem. Biophys. 39, 13–22 (2003).
Croizat, H. & Nagel, R.L. Am. J. Hematol. 60, 105–115 (1999).
Hoh, J. & Ott, J. Nat. Rev. Genet. 4, 701–709 (2003).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Meschia, J., Pankratz, V. Defining stroke risks in sickle cell anemia. Nat Genet 37, 340–341 (2005). https://doi.org/10.1038/ng0405-340
Issue Date:
DOI: https://doi.org/10.1038/ng0405-340
