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Reply to “STOX1 is not imprinted and is not likely to be involved in preeclampsia”

Nature Genetics volume 39, pages 280–281 (2007)Cite this article

van Dijk et al. reply:

We have read with great interest the correspondence by Moore and co-workers1. Indeed, the presence of the CC (Y153H) genotype in uncomplicated pregnancies, as we have previously noted, is contradictory1,2. However, our original conclusion, that the Y153H variation in the DNA binding domain of the winged helix protein encoded by STOX1 is involved in the etiology of preeclampsia, may still hold, for the following reasons.

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Author information

Authors and Affiliations

  1. Department of Clinical Chemistry, Vrije University Medical Center, De Boelelaan 1117, Amsterdam, 1081 HV, The Netherlands

    Marie van Dijk, Jan van Bezu, Marinus A Blankenstein & Cees B M Oudejans

  2. Department Obstetrics and Gynecology, The Chinese University of Hong Kong, Shatin, Hong Kong, China

    Stephen S Chim

  3. Department of Chemical Pathology, The Chinese University of Hong Kong, Shatin, Hong Kong, China

    Y M Dennis Lo

Authors
  1. Marie van Dijk
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  2. Jan van Bezu
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  3. Stephen S Chim
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  4. Y M Dennis Lo
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  5. Marinus A Blankenstein
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  6. Cees B M Oudejans
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Competing interests

Y.M.D.L. and S.S.C. have filed patent applications on epigenetic markers for prenatal monitoring. The VU Medical Center has filed a patent application related to a method for diagnosing preeclampsia.

Supplementary information

Supplementary Fig. 1

The STOX1 CpG island is unmethylated.

Supplementary Methods

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van Dijk, M., van Bezu, J., Chim, S. et al. Reply to “STOX1 is not imprinted and is not likely to be involved in preeclampsia”. Nat Genet 39, 280–281 (2007). https://doi.org/10.1038/ng0307-280

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