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Genetics and epigenetics of hydatidiform moles

Nature Genetics volume 38, pages 274–276 (2006)Cite this article

Human embryos that develop in the presence of chromosomes solely of paternal origin give rise only to a disorganized mass of placental derivatives known as a complete hydatidiform mole. A new study reports that mutations in NALP7, a gene thought to be involved in inflammatory and apoptotic pathways, occur in human females whose biparental conceptuses can develop as apparent complete moles.

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Figure 1: A complete hydatidiform mole resulting from development in the presence of two sets of paternal chromosomes and no maternal chromosomes.

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Authors and Affiliations

  1. Department of Genetics and Development College of Physicians and Surgeons, Columbia University, 701 West 168th Street, New York, 10032, New York, USA

    Timothy H Bestor

  2. Institut National de la Santé et de la Recherche Médicale, U741, Paris 7 University, 2 Place Jussieu, Paris, 75251, Cedex 05, France

    Déborah Bourc'his

Authors
  1. Timothy H Bestor
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  2. Déborah Bourc'his
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Bestor, T., Bourc'his, D. Genetics and epigenetics of hydatidiform moles. Nat Genet 38, 274–276 (2006). https://doi.org/10.1038/ng0306-274

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