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Multiple self–healing squamous epitheliomata (ESS1) mapped to chromosome 9q22–q31 in families with common ancestry

Nature Genetics volume 3, pages 165–169 (1993)Cite this article

Abstract

A gene (ESS 1) predisposing to the development of multiple invasive but self–healing skin tumours (squamous cell epitheliomata) is tightly linked to the polymorphic DNA marker D9S53 (9q31) with a maximum lod score of 9.02 at a recombination fraction of 0.03. Multipoint linkage analysis demonstrates that the disease locus is most likely to lie between D9S58 (9q22.3–31) and ASSP3 (9q11–q22). Comparison of markers associated with ESS1 in independently ascertained families suggests a common origin of the disease and defines the location of ESS1. Haplotype studies indicate that the disease locus is most likely to lie between D9S29 (9q31) and D9S1 (9q22.1–q22.2).

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Authors and Affiliations

  1. Imperial Cancer Research Fund Genetic and Tumour Virus Pathology Unit, Cambridge University, Tennis Court Road, Cambridge, CB2 1QP, UK

    David R. Goudie, Martin A.R. Yuille, Margaret A. Leversha, Robert A. Furlong, Nigel P. Carter, Michael J. Lush, Nabeel A. Affara & Malcolm A. Ferguson-Smith

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  1. David R. Goudie
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  2. Martin A.R. Yuille
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  3. Margaret A. Leversha
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  4. Robert A. Furlong
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  5. Nigel P. Carter
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  6. Michael J. Lush
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  7. Nabeel A. Affara
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  8. Malcolm A. Ferguson-Smith
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Goudie, D., Yuille, M., Leversha, M. et al. Multiple self–healing squamous epitheliomata (ESS1) mapped to chromosome 9q22–q31 in families with common ancestry. Nat Genet 3, 165–169 (1993). https://doi.org/10.1038/ng0293-165

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