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Telomere-binding factors and general DNA repair

Nature Genetics volume 37, pages 116–118 (2005)Cite this article

Telomeres cap the ends of linear chromosomes and prevent them from being recognized as double-strand breaks needing repair. How they go about hiding the ends from the DNA-repair apparatus is becoming a broader question, as a new study identifies an increasingly incestuous relationship between DNA-repair factors and telomere-binding proteins.

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Figure 1: Telomere-binding factors (green) and the DNA-repair factors they recruit to telomeres (red) function to inhibit rather than promote a variety of repair processes.

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Authors and Affiliations

  1. the Department of Cell Biology, University of Texas Southwestern Medical Center at Dallas, 5323 Harry Hines Boulevard, Dallas, 75390-9039, Texas, USA

    Woodring E Wright & Jerry W Shay

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  1. Woodring E Wright
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  2. Jerry W Shay
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Wright, W., Shay, J. Telomere-binding factors and general DNA repair. Nat Genet 37, 116–118 (2005). https://doi.org/10.1038/ng0205-116

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